Warsaw Medical Physics Meeting 2015

14-05-2015 09:00 to 16-05-2015 16:00

Center of New Technologies
Warsaw, Poland

Registration

  • 14-05-2015 08:30

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Coffee break

  • 14-05-2015 09:00

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Welcome Ceremony

  • 14-05-2015 09:30

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1st plenary session

  • 14-05-2015 09:45

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Radiometals - production methods optimized for small medical cyclotron

  • 14-05-2015 09:45

            The development of biological targeting agents such as proteins, peptides, antibodies and nanoparticles contributing in vivo processes lasting many hours and days demands the production of radionuclides with radioactive half-lives complementary to these biological properties.  Potentially useful radiometals include nuclides such as Zirconium 89 (89Zr), Yttrium 86 (86Y) and Copper 64 (64Cu). In the presented project, optimal methods of cyclotron target production for these radiometals...

Automated environment control using a multi-agent system for radiopharmaceuticals production

  • 14-05-2015 10:25

This paper discusses the development of an automated monitoring system in order to ensure a cGMP compliant environment inside a radiopharmaceuticals production facility. One promising technique for controlling the environment key parameters is through the use of autonomous, intelligent software agents together with an environment model. When disturbances occurs agents will react to the environment changes and automatically take action for restoring the normal values for the pressure cascades, a...

Targeting αvβ3 integrin receptors using Ga-68 labelled RGD peptides

  • 14-05-2015 10:50

The aim of this study was to target the αvβ3 integrin on tumor cells in the frame of diagnostic imaging. Due to its overexpression at the surface of cancer cells and osteoclasts, integrin αvβ3 is a bio-active receptor in several pathologic processes related to tumor growth and methastasis. As a specific transporter c(RGD)2 coupled with DOTA was used and radiolabelled with Ga-68, through automated synthesis, obtaining a PET radiotracer. During this study the eluate from an anorganic column based...

Production of positrons emitters 43Sc and 44Sc for medical imaging with the alpha particle beam - evaluation of process efficiency

  • 14-05-2015 11:15

The paper discusses the process of production of 43Sc on natural calcium targets with alpha particle beam at the Warsaw cyclotron in Heavy Ion Laboratory. This radioisotope is similar to 18F and 68Ga but comes with longer T1/2 and has increased uptake characteristics for some cancers. So far, 43Sc is mainly obtained on expensive, enriched calcium targets. Natural calcium is cheaper and the reaction additionally produces 44Sc – a radioisotope considered significant in upcoming techniques of three...

Coffee break

  • 14-05-2015 11:40

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2nd plenary session

  • 14-05-2015 12:00

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The dark side of the moon: risk of cancer induced by external beam radiotherapy of tumours

  • 14-05-2015 12:00

Andrzej Wojcik1, Iuliana Toma-Dasu2 and Alexandru Dasu3 1: Centre for Radiation Protection Research, MBW Department, Stockholm University; 2: Medical Radiation Physics, Department of Physics, Stockholm University; 3: Department of Radiation Physics and Department of Medical and Health Sciences, Linköping University and Skandionkliniken, Uppsala, Sweden.   Nearly two-thirds of all cancer patients will receive radiation therapy during their illness. But ionising radiation is a two-edged sword: ...

Spatiotemporal dynamics of DNA damage in cells exposed to mixed beams of ionising radiations

  • 14-05-2015 12:40

The goal of this study is to analyse the kinetics of formation and repair of ionising radiation-induced foci (IRIF) in cells exposed to alpha particles, X rays and a mixed beam of both radiations. The hypothesis is that exposure to a mixed beam induces complex DNA damage above the level expected from the additive action of both radiations and the results of this analysis will be presented. The measurements are performed with human cells transfected with a plasmid coding for the DNA repair protei...

Protective effect of melatonin on γ radiation-induced sperm malformations in C57BL/6 male mice

  • 14-05-2015 13:05

Ritu Kushwaha, Dhruv K Nishad, Aseem BhatnagarBackground: Melatonin, a compound known for its antioxidant properties, scavenges free radicals and counteracts the generation of free radicals by inhibiting activity of the nitric oxide synthase.Objective: This study is intended to assess the protective efficacy of melatonin against the γ radiation induced alterations in the morphological characteristics of sperm in the cauda epididymis of C57Bl/6 mice.Materials and Methods: C57BL/6 male mice (n=12)...

LUNCH

  • 14-05-2015 13:30

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3rd plenary session

  • 14-05-2015 14:15

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Does CTV-PTV margin have an impact on estimation of cumulated dose distribution?

  • 14-05-2015 14:15

The purpose of this work was to test whether the CTV-PTV margin has an impact on estimation of cumulated dose distribution (CDDall). For patients with prostate cancer treated in our clinic set-up errors were recorded. For each patient treatment plans in three techniques were prepared: 3D-CRT, IMRT and VMAT. We prepared plans for different CTV-PTV margin: 0, 0.2, 0.4, 0.6, 0.8, 1.0 cm. For each treatment plan and each fraction the dose distribution was calculated with the isocenter corrected for ...

Influence of prostate rotation on dose distribution in the target volume

  • 14-05-2015 14:40

E. Dąbrowska1,2, B. Brzozowska2, B. Chaber3, P. Kukołowicz1, J. Starzyński3, A. Zawadzka1 1 Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Medical Physics 2 University of Warsaw, Department of Biomedical Physics 3 Faculty of Electrical Engineering, Warsaw University of Technology The inter-fraction prostate motion can have a significant impact on dose distribution in the target volume. However, the concept of the PTV was developed to minimize the influen...

Coffee break

  • 14-05-2015 15:05

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poster session

  • 14-05-2015 15:30

Monitoring of Indoor radon concentrations in Samawa oil refinery Premises and city dwellings , Iraq Abdulameer Kazem Farhood Co - Authors :  Lect.  Laith M. Rasheed Abstract: Contribution of radon and it's radioactive progenies have been found to pose severe health hazards in the indoor environments. It is an established fact that besides air, water, soil, and rocks, naturally occurring radio nuclides are also associated with the petroleum extracted from the sedimentary deposits. There...

Coffee break

  • 15-05-2015 09:15

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4th plenary session

  • 15-05-2015 09:40

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Dose verification to cochlea during gamma knife radiosurgery of the internal auditory canal using ionization chamber and diode and mirco diamond detectors.

  • 15-05-2015 09:40

Our aim in this study was to verify the absorbed dose to cochlea of the treatment planning system (TPS) during gamma knife radiosurgery of acoustic schwannoma using ionization chamber, diode measurements and a micro diamont detector. The cochlea is a high risk organ which will be saved by treatments of acustic schwannomas by the Gamma Knife radiosurgery unit. Materials and Methods: A human cadaver head and an Alderson phantom were prepared by drilling a hole of 8 mm diameter to the cochlea to pl...

Nanoparticles as radiosensitizers in radiation therapy

  • 15-05-2015 10:05

The effectiveness of radiotherapy can be improved by radiosensitization of tumor cells. High-Z materials, which may be delivered to the tumor in the form of nanoparticles, are capable of intensifying the emission of secondary and Auger electrons after the X-ray irradiation. Gold nanoparticles gained the greatest recognition as potential radiosensitizers, but platinum or gadolinium-based particles are also considered for this purpose. Nanoparticles are coated with polymers in order to improve the...

Coffee break

  • 15-05-2015 10:30

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5th plenary session

  • 15-05-2015 10:50

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Professional profile of Portuguese Radiation Therapists, competence related professional issues linked to ESTRO RTT core curriculum

  • 15-05-2015 10:50

Background and Purpose: The continuous development and innovations in Radiation Oncology requires well trained and specialized practitioners. Among the multidisciplinary team, the Radiation Therapist (RTT) requires adequate knowledge and skills, to develop clearer and well defined roles, professionalism and clinical competences within the field of practice. The Core Curriculum (CC) recommended by ESTRO was published to promote and establish a standard that should be recognized and used by Europe...

Texture analysis of CT perfusion in head and neck cancer patients

  • 15-05-2015 11:30

The response to radiotherapy depends on the tumor physiology. The aim of this project was to compare second order statistical texture parameters in CT perfusion of head and neck patients with respect to tumor site, stage and human papillomavirus (HPV) status. Energy, entropy, contrast and correlation were calculated using Python. Median values, as the standard first order parameter, were calculated for comparison. Data for 42 patients was analyzed (n=17 oropharynx, n=7 hypopharynx, n=9 larynx, n...

Comparative studies of FE boards for use of J-PET scanner

  • 15-05-2015 11:55

The Jagiellonian Positron Emission Tomograph (J-PET) prototype based on plastic scintillators is currently under development at the Jagiellonian University (see e.g. [1,2]). Each J-PET module consists of long polymer scintillator strip with fast photomultipliers connected to each end. Due to very good timing properties of each module, a new kind of front end board is needed to not diminish spacial resolution of the scanner. Three different approaches to probe signal shapes will be presented: mul...

Coffee break

  • 15-05-2015 12:20

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6th plenary session

  • 15-05-2015 12:40

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Optimization of Levels of Voltage Thresholds in a Novel J-PET Device

  • 15-05-2015 12:40

Nowadays, in Positron Emission Tomography (PET) systems, a Time of Flight (TOF) information is used to improve the image reconstruction process. A novel concept, called J-PET scanner, offers an improvement of TOF resolution due to the use of fast plastic scintillators and dedicated electronics allowing for sampling the signals in the voltage domain [1,2,3]. Owing to Compress Sensing theory, the full waveforms of the signals are recovered [4]. In the presentation we will demonstrate that with fu...

Novel J-PET plastic scintillator with 2-(4-styrylphenyl)benzoxazole as a wavelength shifter

  • 15-05-2015 13:05

Plastic scintillators are the key part of positron emission tomography device which is being constructed at the Jagiellonian University. Experiments confirmed that low detection efficiency and slight probability of photoelectric effect do not prevent the use of plastic scintillators as detectors for 511 keV gamma quanta [1]. The novelty of the J-PET scintillator concept lies in the application of 2-(4-styrylphenyl)benzoxazole as a wavelength shifter [2]. Properties of the J-PET scintillators wi...

LUNCH

  • 15-05-2015 13:30

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7th plenary session

  • 15-05-2015 14:15

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Application of the 4D Flow visualisation in cardiology.

  • 15-05-2015 14:15

The 4D Flow technique is a MRI method of imaging blood flow in three dimensions and time over an averaged heart cycle. It provides information about three directions of blood’s velocity. The method allows for qualitative assessment of the flow of blood through the whole imaged region. 4D Flow data gives the possibility of creating three-dimensional visualisations of the blood flow, e.g. streamlines and pathlines. Even though the method still faces some challenges (such as long acquisition times ...

Evaluation of cardiac motion in MRI

  • 15-05-2015 14:40

Heart motion can be observed on a series of dynamic images acquired using Cardiac Magnetic Resonance Imaging (CMRI). Though global motion biomarkers, such as stroke volume or ejection fraction, are used in everyday clinic diagnosis, there are no popular parameters describing local motion of the cardiac muscle. In tagged MRI technique, spatial modulation of magnetization is used to create tag lines. Tag lines move with the tissue making both motion observation and quantitative motion estimation m...

Conference dinner

  • 15-05-2015 20:00

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Coffee break

  • 16-05-2015 09:30

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8th plenary session

  • 16-05-2015 10:00

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Thyroid Remnants Therapeutic Dose Determination Using a Small Field of Gamacamera; Pilot Study

  • 16-05-2015 10:00

Authors: P. Solny1,2, P. Vlček1, J. Zimák1, L. Jonášová1; 1Clinic of Nuclear Medicine and Endocrynology, Prague, CZECH REPUBLIC, 2Department of Dosimetry and Application of Ionizing Radiation Faculty of Nuclear Sciences and Physical Engineering, Czech Technical University, Prague, CZECH REPUBLIC.   The aim of this pilot study was to investigate and verify the possibilities of dosimetry for patients undergoing first Radioiodine therapy (RAIT) using a sm...

Characterization of the spatial resolution of the J-PET detector

  • 16-05-2015 10:25

A prototype of the positron emission tomography device based on plastic scintillators is currently being developed at the Jagiellonian University [1-3]. Point Spread Function (PSF) determined for the detector with different scintillator shapes will be shown. PSF can be used both to determine and to improve spatial resolution in PET scanners [4]. Spatial resolution of the J-PET prototype was determined using two 22Na radioactive isotopes placed inside the detector. [1] P. Moskal, S. Niedźwick...

Coffee break

  • 16-05-2015 10:50

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9th plenary session

  • 16-05-2015 11:10

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Performance of the 24-module prototype of the J-PET detector

  • 16-05-2015 11:10

A prototype of Positron Emission Tomography scanner is being developed by the J-PET collaboration at the Jagiellonian University [1,2,3,4]. The J-PET detector is built out of plastic scintillators characterized by good timing properties. The reconstruction of the hit-position of gamma quanta is based predominantly on the measurement of the time of registered signals. In order to reconstruct proper hit-position of the gamma quanta the time synchronization of many detector modules is needed. Meth...

Radiation protection dosimetry using recombination chambers at radiotherapy facilities

  • 16-05-2015 11:35

Recombination chambers give possibility to perform measurements for various purposes of radiation protection of patient, medical personnel, bystanders and other people. Radiation protection with help of large tissue equivalent detectors gives not only dose but also ambient dose equivalent. Secondary cancer risk of not treated organs could be recognized with small in-phantom chambers or ring-shape recombination chamber specially designed for dose delivered to optic nerve in proton-eye-therapy. An...

LUNCH

  • 16-05-2015 12:15

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10th plenary session

  • 16-05-2015 13:00

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Performance characteristics of J-PET detector simulated using GATE package

  • 16-05-2015 13:00

Novel PET system based on plastic scintillators is developed by the J-PET collaboration [1,2]. In order to determine performance characteristics of built scanner prototype, advanced computer simulations must be performed. Simulations are performed using GATE software (Geant4 Application for Tomographic Emission) in CIŚ cluster (Świerk Computing Centre at National Centre for Nuclear Research). Performance of any PET scanner may be evaluated inter alia using dependencies between true, scattered...

Informative and non-informative priors in bayesian statistics: Application in cytogenetic biological dosimetry of mixed n + γ radiation

  • 16-05-2015 13:25

Iwona Pacyniak1, Krzysztof W. Fornalski2, Maria Kowalska11Centrl Laboratory for Radiological Protection, Warsaw2PGE EJ 1, WarsawMixed radiation n+g comes mainly from nuclear reactors. These two types of radiation have different properties and also different biological effectiveness. In case of exposure of people to this kind of radiation it is very important to assess not only the total absorbed dose but also neutron and gamma contribution. It is possible by using iterative method and also bayes...

Coffee break

  • 16-05-2015 13:50

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Closing ceremony

  • 16-05-2015 14:10

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